oxidative stress (os), which has been implicated in pathogenesis of many acute and chronic diseases, plays an important role in diverse neurological disorders including depression and anxiety. os is caused by a large amount of reactive oxygen species or impaired enzymatic or non-enzymatic defense against it. os has been suggested to contribute to etiology of mentioned disorders. this review int...

many studies concerning persian history have been performed. persian physicians and scientists greatly contributed to medical sciences by their own observations, experimentations and skills through more than seven thousand years of persian history. in persian medieval medicine, different fields were described. among these fields, neurological disorders, especially headache and epilepsy were exp...

how to cite this article: karimzadeh p. approach to neurometabolic diseases from a pediatric neurological point of view. iran j child neurol. 2015 winter;9(1): 1-16.   abstract objective neurometabolic disorders are an important group of diseases that mostly are presented in newborns and infants. neurological manifestations are the prominent signs and symptoms in this group of diseases. seizure...

metabotropic glutamate receptors (mglurs) consist of a large family of g-protein coupled receptors that are critical for regulating normal neuronal function in the central nervous system. the wide distribution and diverse physiological roles of various mglur subtypes make them highly attractive targets for the treatment of a number of neurological and psychiatric disorders. the discovery of sub...

Pediatric neurological disorders including muscular dystrophy, cerebral palsy, and spinal cord injury are defined as a heterogenous group of diseases, of which some are known to be genetic. The two significant features represented for stem cells, leading to distinguish them from other cell types are addressed as below: they can renew themselves besides the ability to differentiate into cells wi...

Historically, policy makers and researchers have used mortality statistics as the principal measure of the seriousness of diseases, based on which countries and organizations have launched disease control programs. Mortality statistics alone, however, underestimate the suffering caused by diseases that may be nonfatal but cause substantial disability. Many neurological and psychiatric condition...